解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Dibenz[a,h]anthracene (DB[a,h]A) is a polycyclic aromatic hydrocarbon that is a by-product of combustion and a potent carcinogen. Few studies have investigated the effects of DB[a,h]A on mRNA and microRNA expression to dissect the mechanisms involved in carcinogenesis. In this study, mature male mice (Muta(™)Mouse) we...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/get031
更新日期:2013-09-01 00:00:00
abstract::The single-cell gel electrophoresis--the comet assay--has proved to be a sensitive and relatively simple method that is much used in research for the analysis of specific types of DNA damage, and its use in genotoxicity testing is increasing. The efficiency of the comet assay, in terms of number of samples processed p...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/get012
更新日期:2013-05-01 00:00:00
abstract::Recent studies suggest increased cancer risk in patients with type 2 diabetes mellitus (T2DM) compared with healthy individuals. The present study aims to assess whether T2DM is associated with increased genome instability and whether a healthy diet with natural foods can improve genome stability in peripheral blood l...
journal_title:Mutagenesis
pub_type: 杂志文章,随机对照试验
doi:10.1093/mutage/ges073
更新日期:2013-03-01 00:00:00
abstract::Many chronic inflammatory conditions are associated with an increased risk of cancer development. At the site of inflammation, cellular DNA is damaged by hypochlorous acid (HOCl), a potent oxidant generated by myeloperoxidase. 8-Chloro-2'-deoxyguanosine (8-Cl-dG) is a major DNA adduct formed by HOCl and has been detec...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/ges056
更新日期:2013-01-01 00:00:00
abstract::The use of DNA adduct analysis has previously focused on the use of marine organisms for biomonitoring, whereas similar investigations in freshwater organisms are sparse. In that context, we have investigated the relevance of DNA adducts as biomarkers of genotoxicity in the freshwater mussels Dreissena polymorpha. The...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/ges036
更新日期:2012-11-01 00:00:00
abstract::Studies in mono-culture of cells have shown that diesel exhaust particles (DEPs) increase the production of reactive oxygen species (ROS) and oxidative stress-related damage to DNA. However, the level of particle-generated genotoxicity may depend on interplay between different cell types, e.g. lung epithelium and immu...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/ges035
更新日期:2012-11-01 00:00:00
abstract:UNLABELLED:Gastric cancer is the second leading cause of cancer-related death worldwide with a low 5-year survival (S5y) after initial diagnosis. Although aberrant Wnt/β-catenin (CTNNB1) signaling has been observed in multiple human cancers, there is no information on the role of CTNNB1 polymorphisms in gastric cancer ...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/ges027
更新日期:2012-11-01 00:00:00
abstract::The search for micronuclei (MN) in binucleated cells is not always the best choice to recognize microtubule-perturbing agents, as they give rise to (micronucleated) mononucleated cells, mainly via mitotic slippage. We therefore treated peripheral lymphocytes with vincristine (VCR), nocodazole (NOC) and colcemid (COL):...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/ges044
更新日期:2012-11-01 00:00:00
abstract::Newborns have to cope with hypoxia during delivery and a sudden increase in oxygen at birth. Oxygen will partly be released as reactive oxygen species having the potential to cause damage to DNA and proteins. In utero, increase of most (non)-enzymatic antioxidants occurs during last weeks of gestation, making preterm ...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/ges022
更新日期:2012-09-01 00:00:00
abstract::Vitamins with antioxidant properties have the ability to act as pro-oxidants, inducing oxidative damage and oxidative stress as opposed to preventing it. While vitamin supplements are commonly consumed, the scientific evidence for their health beneficial effects is inconclusive. In fact, even harmful effects have been...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/ges013
更新日期:2012-07-01 00:00:00
abstract::The Ser326Cys polymorphism in the human 8-oxogunaine DNA glycosylase (hOGG1) gene had been implicated in cancer susceptibility. Studies investigating the associations between the Ser326Cys polymorphism and cancer susceptibility showed conflicting results. To derive a more precise estimation of the relationship, a meta...
journal_title:Mutagenesis
pub_type: 杂志文章,meta分析
doi:10.1093/mutage/ger083
更新日期:2012-05-01 00:00:00
abstract::Despite their prime candidate status, polymorphisms near genes involved in DNA repair or in other functions related to genome stability have been conspicuously under-represented in the significant associations reported from genome-wide association studies (GWAS) of cancer susceptibility. In this study, we assessed a s...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/ger070
更新日期:2012-03-01 00:00:00
abstract::The ability of topoisomerase II inhibitor, teniposide, to induce aneuploidy and meiotic delay in somatic and germinal cells of male mice was investigated by fluorescence in situ hybridisation (FISH) assay using labelled DNA probes and 5-bromo-2'-deoxyuridine (BrdU) incorporation assay, respectively. Colchicine and mit...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/ger051
更新日期:2012-01-01 00:00:00
abstract::Cell transformation assays (CTAs) have long been proposed as in vitro methods for the identification of potential chemical carcinogens. Despite showing good correlation with rodent bioassay data, concerns over the subjective nature of using morphological criteria for identifying transformed cells and a lack of underst...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/ger053
更新日期:2012-01-01 00:00:00
abstract::Nitro-polycyclic aromatic hydrocarbons (nitro-PAHs) are mutagenic and carcinogenic environmental pollutants found in diesel exhaust and on urban air pollution particles. In the present study, human bronchial epithelial BEAS-2B cells were exposed to 2-nitrobenzanthrone (2-NBA) and 3-nitrobenzanthrone (3-NBA). DNA damag...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/ger035
更新日期:2011-11-01 00:00:00
abstract::Cyclooxygenase 2 (Cox-2, a rate-limiting enzyme in the conversion of arachidonic acid to prostanoids) has been implicated in several physiological and pathological processes, and it has been reported that polymorphisms in the regulatory region of Cox-2 might influence its expression, contributing to the interindividua...
journal_title:Mutagenesis
pub_type: 杂志文章,meta分析
doi:10.1093/mutage/ger040
更新日期:2011-11-01 00:00:00
abstract::The International Agency for Research on Cancer has classified several antineoplastic drugs in Group 1 (human carcinogens), among which chlorambucil, cyclophosphamide (CP) and tamoxifen, Group 2A (probable human carcinogens), among which cisplatin, etoposide, N-ethyl- and N-methyl-N-nitrosourea, and Group 2B (possible...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/geq102
更新日期:2011-05-01 00:00:00
abstract::In the past decade, a number of case-control studies have been carried out to investigate the relationship between the HHEX polymorphism and type 2 diabetes (T2D). However, the results have been inconclusive. To investigate this inconsistency, we performed a meta-analysis of all available studies dealing with the rela...
journal_title:Mutagenesis
pub_type: 杂志文章,meta分析
doi:10.1093/mutage/geq095
更新日期:2011-03-01 00:00:00
abstract::The cytokinesis-block micronucleus cytome (CBMNCyt) assay is a widely used technique for measuring DNA damage in human populations. The formation of micronuclei (MN) in dividing cells can result from chromosome breakage due to unrepaired or mis-repaired DNA lesions or chromosome malsegregation due to mitotic malfuncti...
journal_title:Mutagenesis
pub_type: 杂志文章,评审
doi:10.1093/mutage/geq076
更新日期:2011-01-01 00:00:00
abstract::The micronucleus test (MNT) is a well-established assay in genotoxicity testing and human biomonitoring. The cytokinesis-block micronucleus test (CBMNT) is the preferred method for measuring MN in cultured human lymphocytes from human subjects exposed to genotoxins. However, it is unclear to what extent mutagen exposu...
journal_title:Mutagenesis
pub_type: 杂志文章,评审
doi:10.1093/mutage/geq061
更新日期:2011-01-01 00:00:00
abstract::The toxicological relevance of the micronucleus (MN) test is well defined: it is a multi-target genotoxic endpoint, assessing not only clastogenic and aneugenic events but also some epigenetic effects, which is simple to score, accurate, applicable in different cell types. In addition, it is predictive for cancer, ame...
journal_title:Mutagenesis
pub_type: 杂志文章,评审
doi:10.1093/mutage/geq068
更新日期:2011-01-01 00:00:00
abstract::Many chemical carcinogens require metabolic activation to form genotoxic compounds in human. Standard in vitro genotoxicity assays performed with activation systems, such as rat liver S9, are recognised to lead to a high number of false positives. The aim of this study was to evaluate the suitability of differentiated...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/geq039
更新日期:2010-11-01 00:00:00
abstract::Well-established in vitro methods for testing the genotoxic potency of chemicals--such as the Ames/Salmonella test, the mouse lymphoma assay, the micronucleus test and the chromosomal aberration test--show a high false-positive rate for predicting in vivo genotoxicity and carcinogenicity. Thus, there is a need for mor...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/geq040
更新日期:2010-11-01 00:00:00
abstract::Monitoring oxidative stress in vivo is made easier by the ability to use samples obtained non-invasively, such as urine. The analysis of DNA oxidation, by measurement of oxidized 2'-deoxyribonucleosides in urine, particularly 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), has been reported extensively in the literatur...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/geq031
更新日期:2010-09-01 00:00:00
abstract::In vivo genotoxicity studies-shortly followed by carcinogenicity-are posing high demand for test-related recourses in terms of animal lives and resources. Among those, the micronucleus test in rodents is the most widely used as a follow-up to positive in vitro mutagenicity results; therefore, the development and exten...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/geq010
更新日期:2010-07-01 00:00:00
abstract::Radiation-induced bystander effects have been evaluated extensively, including the involvement of the mitogen-activated protein kinase (MAPK) pathways. However, few studies have examined the ability of chemicals to induce bystander effects, and the molecular mechanisms involved in chemical bystander effects have not b...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/geq003
更新日期:2010-05-01 00:00:00
abstract::The induction of localized DNA damage within a discrete nuclear volume is an important tool in DNA repair studies. Both charged particle irradiation and laser microirradiation (LMI) systems allow for such a localized damage induction, but the results obtained are difficult to compare, as the delivered laser dose canno...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/geq005
更新日期:2010-05-01 00:00:00
abstract::The accumulation of mitochondrial DNA (mtDNA) mutations has been proposed as an underlying cause of the ageing process and mutations have been associated with cancer in many tissues, including human skin. This involvement is linked to the key roles of mitochondrial function and mtDNA in oxidative stress production and...
journal_title:Mutagenesis
pub_type: 杂志文章,评审
doi:10.1093/mutage/gep061
更新日期:2010-03-01 00:00:00
abstract::The objective of the present study was to develop a cellular phenotype assay for nucleotide excision repair (NER), using benzo[a]pyrene diol epoxide (BPDE) as model mutagen. Since in vitro exposure to BPDE may lead to DNA strand breaks resulting from both direct interaction with DNA and incisions introduced by the rep...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gep039
更新日期:2010-01-01 00:00:00
abstract::Published data regarding the association between the apurinic/apyrimidinic endonuclease 1 (APE1) T1349G (Asp148Glu) polymorphism and cancer risk show inconclusive results. To derive a more precise estimation of the relationship, we performed a meta-analysis of 27 published studies that included 12 432 cancer cases and...
journal_title:Mutagenesis
pub_type: 杂志文章,meta分析
doi:10.1093/mutage/gep036
更新日期:2009-11-01 00:00:00
abstract::The development of novel nanomaterials with unique physico-chemical properties is increasing at a rapid rate, with potential applications across a broad range of manufacturing industries and consumer products. Nanomaterial safety is therefore becoming an increasingly contentious issue that has intensified over the pas...
journal_title:Mutagenesis
pub_type: 杂志文章,评审
doi:10.1093/mutage/gep010
更新日期:2009-07-01 00:00:00
abstract::Alcohol drinking-derived acetaldehyde is believed to cross-link DNA and induce sister chromatid exchanges in peripheral blood lymphocytes. However, little population data are available to illustrate effects of alcohol-derived acetaldehyde on DNA migration as assayed by the comet assay in peripheral lymphocytes. In the...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gep008
更新日期:2009-07-01 00:00:00
abstract::Barrett's oesophagus (BO) carries an increased risk of progression to oesophageal adenocarcinoma. Chromoendoscopy with methylene blue (MB) can be used to facilitate identification of BO and target areas for biopsy. If photoexcited, MB can generate reactive oxygen species and genotoxic photodegradation products leading...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gep004
更新日期:2009-05-01 00:00:00
abstract::The importance of diet in DNA damage prevention is well established; however, the comparison of weight loss diets with different micronutrient and macronutrient profiles on genome stability in peripheral blood lymphocytes (PBLs) has not been studied. This study tested the hypothesis that genome stability in PBLs of ov...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gep006
更新日期:2009-05-01 00:00:00
abstract::Fanconi anaemia (FA) patients show cellular sensitivity to a variety of clastogens and prominently to cross-linking agents. Although there is a long-standing clinical impression of radiosensitivity, in vitro studies have yielded conflicting results. In this study, initial radiation-induced DNA damage and kinetics of D...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gen052
更新日期:2009-01-01 00:00:00
abstract::The partial hepatectomy method, co-treatment method with mitogens and an in vivo/in vitro assay method have been reported as in vivo liver micronucleus (MN) assays. These methods have disadvantages with respect to widespread use as an in vivo assay, i.e. they are time consuming, labour intensive and there is the possi...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gen047
更新日期:2009-01-01 00:00:00
abstract::A perceived disadvantage of transgenic rodent mutation assays is that spontaneous mutant frequencies are high compared to those of endogenous genes and may consequently reduce sensitivity to induced mutation. We have previously argued that unrepaired G:T mismatches from spontaneous deamination of 5-methylcytosine at C...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gen026
更新日期:2008-09-01 00:00:00
abstract::We report on a new method for the study of radiation-induced chromatid breaks in stimulated human peripheral blood T lymphocytes, involving a combination of a 1-h colcemid block and a short (15 min) calyculin A treatment. We find that this procedure eliminates the problem of centromere splitting when calyculin A is us...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gen009
更新日期:2008-07-01 00:00:00
abstract::Protection from chronic exposure to cosmic radiation, which is primarily composed of protons, in future manned missions to Mars and beyond is considered to be a key unresolved issue. To model the effects of cosmic radiation on a living cell, we used Saccharomyces cerevisiae cells harboring various deletions of DNA rep...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gem055
更新日期:2008-03-01 00:00:00
abstract::The Mre11 complex (Mre11-Rad50-Nbs1) is involved in a diverse array of DNA metabolic processes including the response to DNA double-strand breaks (DSBs). The structure of Rad50 plays a key role in the DNA-binding and end-bridging activity of the complex. An interesting feature within the central portion of the Rad50 p...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gem011
更新日期:2007-07-01 00:00:00